PARG-IN-6

• Target:

  Poly (ADP-ribose) Glycohydrolase (PARG)

• Related Pathways:

  Cell Cycle/Checkpoint

• Bioactivity:

  PARG-IN-6 (Compound 2) is an orally bioavailable PARG inhibitor with an IC50 of 0.3 nM. It exhibits significant anticancer activity against cancer cells, with an IC50 of 0.0368 ?M for HCC1395 cells. PARG-IN-6 shows potential for research in colon cancer, appendiceal cancer, and pancreatic cancer.

• Smiles:

  N#CC1 (NS (=O) (=O) C2=CC=3C (=NN (C3C (=C2F) C4=C (C) CN (CC4) S (=O) (=O) C (C) C) C) C5=NN=C (S5) C (F) (F) F) CC1

• Molecular Formula:

  C24H25F4N7O4S3

• Molecular Weight:

  647.69

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3083070-66-7