CDK4-IN-3

• CAS Number :

  3002399-75-6

• Target :

  Apoptosis|||CDK

• Related Pathways :

  Cell Cycle/Checkpoint|||Apoptosis

• Bioactivity :

  CDK4-IN-3 (Compound 389) is a highly selective irreversible inhibitor of cyclin-dependent kinase 4 (CDK4) with an IC50 of 25 nM and exhibits more than 10-fold selectivity over CDK6. It arrests the cell cycle at the G1 phase and induces apoptosis in tumor cells. CDK4-IN-3 holds potential for research in solid tumors such as breast and lung cancer.

• Smiles :

  C(C)(C)N1C=2C(C(=O)C(C)=C1C3CCCN3)=CC=C(C2)C4=NC(N[C@H]5[C@H](O)COCC5)=NC=C4F

• Molecular Formula :

  C26H32FN5O3

• Molecular Weight :

  481.56

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C