CDK4-IN-3

• Target:

  Apoptosis|||CDK

• Related Pathways:

  Cell Cycle/Checkpoint|||Apoptosis

• Bioactivity:

  CDK4-IN-3 (Compound 389) is a highly selective irreversible inhibitor of cyclin-dependent kinase 4 (CDK4) with an IC50 of 25 nM and exhibits more than 10-fold selectivity over CDK6. It arrests the cell cycle at the G1 phase and induces apoptosis in tumor cells. CDK4-IN-3 holds potential for research in solid tumors such as breast and lung cancer.

• Smiles:

  C(C)(C)N1C=2C(C(=O)C(C)=C1C3CCCN3)=CC=C(C2)C4=NC(N[C@H]5[C@H](O)COCC5)=NC=C4F

• Molecular Formula:

  C26H32FN5O3

• Molecular Weight:

  481.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3002399-75-6