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ELQ-121

CAT: 0013-GTR19263217-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263217-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ELQ-121 is a potent inhibitor of the ubiquinol oxidation (QO) site in parasites. It exhibits an in vitro IC50 of 0.05 nM against both chloroquine-sensitive and multi-drug resistant Plasmodium falciparum. ELQ-121 also inhibits Toxoplasma gondii and Neospora caninum with an in vitro IC50 of less than 1 nM. It hinders the proliferation of Bacteroides fragilis tachyzoites with an IC50 of 0.49 nM and induces mitochondrial disruption. Furthermore, ELQ-121 can be formulated into a polyethylene glycol carbonate prodrug, which shows efficacy against P. yoelii in mice. ELQ-121 is applicable for antimalarial research.
CAS Number
1228283-36-0
Field of Research
Infectious Disease & Virology
Smiles
O=C1C=2C (F) =CC (F) =CC2NC (=C1CCCCCCC) C
Molecular Formula
C17H21F2NO
Molecular Weight
293.35
Storage Conditions
-20°C
Notes
For research use only.

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