Multitarget AD inhibitor-2

CAT: 0931-T210373-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T210373-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Monoamine Oxidase, Cholinesterase (ChE)

Related Pathways

Neuroscience

Bioactivity

Multitarget AD inhibitor-2 (Compound VN-19) is a versatile inhibitor targeting multiple sites, acting on acetylcholinesterase (AChE, IC50 = 0.14 μM), butyrylcholinesterase (BChE, IC50 = 11.6 μM), and monoamine oxidase B (MAO B, IC50 = 0.45 μM) . It inhibits amyloid-beta protein Aβ1-42 self-induced aggregation with an inhibition rate of 47.3% at 20 μM and reduces ROS levels in SH-SY5Y cells with an inhibition rate of 80% at 25 μM. Multitarget AD inhibitor-2 can also improve cognitive decline in a scopolamine-induced Alzheimer's zebrafish model.

Molecular Formula

C22H23NO4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Multitarget AD inhibitor-2

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