PF-06442609

• Target:

  Gamma-secretase

• Related Pathways:

  Neuroscience|||Stem Cells|||Proteases/Proteasome

• Bioactivity:

  PF-06442609 is an orally active ?-secretase modulator with an IC50 value of 6 nM for A?42. It exhibits good CNS permeability.

• Smiles:

  O=C1N2C(C(=O)N([C@H](COC3=C([C@H](C(F)(F)F)C)C=C(F)C=C3)C)CC2)=CC=C1N4C=NC(C)=C4

• Molecular Formula:

  C24H24F4N4O3

• Molecular Weight:

  492.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1402002-76-9