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HDAC6-IN-45

CAT: 0931-T210266-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210266-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3048532-05-1
Target
HDAC, Nrf2, Reactive Oxygen Species, Apoptosis
Related Pathways
Apoptosis, DNA Damage/DNA Repair, Chromatin/Epigenetic, Immunology/Inflammation, Metabolism, NF-κB
Bioactivity
HDAC6-IN-45 (Compound 15) is a selective inhibitor of HDAC6, with an IC50 of 15.2 nM. It exerts neurotrophic effects by upregulating GAP43 and Beta-3 Tubulin markers. Additionally, HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, and inhibits apoptosis in PC12 cells. In zebrafish models of Alzheimer's disease, it demonstrates neuroprotective properties. Moreover, HDAC6-IN-45 exhibits antioxidant activity and has favorable blood-brain barrier (BBB) permeability.
Smiles
O=C(NO)C1=CC=C(C=C1)CN2CC3=C(C=4C=C(F)C=CC4N3CC5CC5)CC2
Molecular Formula
C23H24FN3O2
Molecular Weight
393.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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