Polθ/PARP-IN-1

CAT: 0931-T209387-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T209387-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

DNA/RNA Synthesis, PARP, Apoptosis

Related Pathways

Chromatin/Epigenetic, DNA Damage/DNA Repair, Apoptosis, Cell Cycle/Checkpoint

Bioactivity

Polθ/PARP-IN-1 (compound 25d) is a potent dual inhibitor of DNA polymerase theta (Polθ) and PARP, with IC50 values of 45.6 nM and 5.4 nM, respectively. This compound exhibits antiproliferative activity, induces apoptosis and cell cycle arrest at the G2/M phase, leading to DNA damage, and demonstrates antitumor properties.

Molecular Formula

C38H33ClFN7O5S

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-161302-01	Polθ/PARP-IN-1
AN200038P	PARP-1/PARP Monoclonal Antibody
MBS5804496	PARP-1-IN-1
YP-W34514-01	Rat POLγ1 (POLγ1) ELISA Kit
311203	PARP, cleaved (ADP-ribosyltransferase 1, ADPRT, ADPRT1, pADPRT-1, PARP, PARP-1, Poly (ADP-ribose) pol, Poly [ADP-ribose] polymerase 1, Poly[ADP-ribose] synthetase 1, PPOL)
311204	PARP, cleaved (Asp214) (ADP-ribosyltransferase 1, ADPRT, ADPRT1, pADPRT-1, PARP, PARP-1, Poly (ADP-ribose) pol, Poly [ADP-ribose] polymerase 1, Poly[ADP-ribose] synthetase 1, PPOL) discontinued
HY-145840	Pol I-IN-1
HY-139593S-01	Polθ-IN-1-d3
M37149-01	PARP-1-IN-4
M33055-01	PARP, PI3K-IN-1

Polθ/PARP-IN-1

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