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LWY713

CAT: 0931-T208355-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T208355-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, FLT, PROTACs
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, PROTAC, Apoptosis
Bioactivity
LWY713 is a PROTAC-based FLT3 degrader (DC50=0.64 nM) that selectively induces FLT3 degradation through a cereblon and proteasome-dependent mechanism. It inhibits cell proliferation and causes G0/G1 phase arrest and apoptosis (apoptosis) in MV4-11 cells. In MV4-11 xenograft models, LWY713 demonstrates significant in vivo antitumor activity. The E3 ligase ligand and linker consist of Lenalidomide-Glycolic acid, while the target protein ligand's active control is NaproxenGilteritinib.
Molecular Formula
C43H54N10O8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-157213LWY713

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