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HDSI-18

CAT: 0931-T207650-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207650-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
HDAC, Apoptosis, Caspase
Related Pathways
Proteases/Proteasome, Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair
Bioactivity
HDSI-18 is an orally active selective inhibitor of HDAC6 with an IC50 of 1.6 nM. It exhibits cytotoxic effects against K562, MV4-11, MOLM-13, THP-1, and Jurkat cells with IC50 values of 0.48, 0.58, 0.91, 1.79, and 4.31 μM, respectively. HDSI-18 can activate Caspase-3, induce mitochondrial depolarization, and trigger apoptosis (Apoptosis), demonstrating antitumor activity.
Molecular Formula
C28H28N4O5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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