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HDSI-18

CAT: 0804-HY-172873Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172873Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDSI-18 is an orally active HDAC6 selective inhibitor (IC50: 1.6 nM) . HDSI-18 is cytotoxic to K562, MV4-11, MOLM-13, THP-1, and Jurkat cells (IC50: 0.48, 0.58, 0.91, 1.79, and 4.31 μM, respectively) . HDSI-18 activates Caspase-3, induces mitochondrial depolarization and apoptosis, and has antitumor activity[1].
UNSPSC
12352211
Target
Apoptosis; Caspase; HDAC
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C1C(CCC(NC2=CC=C(C(NO)=O)C=C2)=O)N(CC3=CC=C(C)C=C3)C(N1CC4=CC=CC=C4)=O
Molecular Formula
C28H28N4O5
Molecular Weight
500.55
References & Citations
[1]Chen C, et al. Design, synthesis and evaluation of structural optimization derived HDAC6 isoform-selective inhibitor. Bioorg Chem. 2025 May 6;161:108562.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6

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