PAD4-IN-5

• Target:

  PAD

• Related Pathways:

  Chromatin/Epigenetic

• Bioactivity:

  PAD4-IN-5 (Example 18) is a PAD4 inhibitor with an IC50 of ?10 nM at 50 µM Ca2+ and 101-500 nM at 1 mM Ca2+ against human PAD4 (hPAD4) . This compound is applicable in the study of autoimmune diseases such as rheumatoid arthritis (RA) .

• Smiles:

  CN1C(C=2N3C=4C(C2)=CC=C(N4)[C@@H](C)NC(=O)[C@]5([C@](CCCCC3)(C5)[H])[H])=NC=6C1=CC7=C(C6)C(=O)N(C[C@H]8COCCN8)CC7

• Molecular Formula:

  C34H41N7O3

• Molecular Weight:

  595.734

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3071873-52-1