Products for Research Use Only
RegisterLogin

YN14-H

CAT: 0931-T206431-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T206431-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Apoptosis, PROTACs, Ras
Related Pathways
MAPK, PROTAC, Apoptosis, GPCR/G Protein
Bioactivity
YN14-H is a PROTAC degrader that targets KRASG12C. It effectively inhibits the growth of NCI-H358 and MIA PaCa-2 cells, with IC50 values of 0.042 μM and 0.021 μM, respectively, and DC50 values of 28.9 nM and 18.1 nM. YN14-H significantly induces apoptosis and suppresses cell migration. It demonstrates favorable pharmacokinetics and excellent in vivo antitumor activity.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T80750-01YN14
T212210-01YN14 (mixture of diastereomers)
TN3764Daphnicyclidin H
T124811-01Lushanrubescensin H
TN4423Laxiracemosin H
T124113-01Desferrioxamine H
TN5467Derrisisoflavone H
TN1648-01Forsythoside H
T126475-01Gnetin H
T71008-01H-87

Alternative Products

CatalogName
GTR19259013-01YN14-H
HY-155356-01YN14
GTR19264519-01YN14 (mixture of diastereomers)
sc-75218H-prune siRNA (h)
sc-58703H-Caldesmon (h-CALD)
sc-29340-PRH-Ras (h) -PR
sc-75218-PRH-prune (h) -PR
sc-37565-PRCENP-H (h) -PR
sc-101013HCAP-H (H-6)
sc-166613Factor H (H-7)

Popular Products