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YN14-H

CAT: 0013-GTR19259013-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19259013-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YN14-H is a PROTAC degrader that targets KRASG12C. It effectively inhibits the growth of NCI-H358 and MIA PaCa-2 cells, with IC50 values of 0.042 μM and 0.021 μM, respectively, and DC50 values of 28.9 nM and 18.1 nM. YN14-H significantly induces apoptosis and suppresses cell migration. It demonstrates favorable pharmacokinetics and excellent in vivo antitumor activity.
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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