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YN14

CAT: 0931-T80750-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T80750-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Ras, PROTACs, Kras
Related Pathways
PROTAC, MAPK, GPCR/G Protein
Bioactivity
YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (ΔG) . It exhibits antiproliferative effects, significantly inhibiting the growth of KRASG12C-mutant cancer cells, and demonstrates tumor regression with tumor growth inhibition (TGI%) rates exceeding 100% in the MIA PaCa-2 xenograft model.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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