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Akt1-IN-8

CAT: 0931-T206415-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206415-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2247688-87-3
Target
Akt
Related Pathways
Cytoskeletal Signaling, PI3K/Akt/mTOR signaling
Bioactivity
Akt1-IN-8 (Compound JL18) is a potent AKT1 kinase inhibitor with oral bioavailability of 41% and an IC50 value of 8.8 nM. It exhibits significant antiproliferative effects against PC-3 prostate cancer cells, with an IC50 of 3.0 μM. Akt1-IN-8 also reduces phosphorylated GSK3β levels.
Smiles
O=C(N1CCN(C=2N=CN=C3NN=C(Br)C32)CC1)C(C4=CC=C(Br)C=C4)CNC(C)C
Molecular Formula
C21H25Br2N7O
Molecular Weight
551.278
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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