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Nurr1 agonist 12

CAT: 0931-T206188-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206188-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
NR4A
Related Pathways
Endocrinology/Hormones
Bioactivity
Nurr1 agonist 12 (Compound 37) acts as an agonist of the nuclear receptor-related protein 1 (Nurr1), enhancing its transcriptional activity with an EC50 of 0.06 μM. It stimulates human response elements NBRE, NurRE, and DR5 with EC50 values of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Additionally, Nurr1 agonist 12 induces the expression of neurotrophic genes regulated by Nurr1, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin) . The compound also demonstrates neuroprotective effects against neurotoxicity caused by Paraquat.
Smiles
O=C(C1=C(Cl)C=C(C=CN2)C2=C1)NC3=CC4=CC=CC=C4N=C3
Molecular Formula
C18H12ClN3O
Molecular Weight
321.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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