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Nurr1 agonist 9

CAT: 0013-GTR19262588-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262588-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nurr1 agonist 9 (Compound 36) acts as an agonist for Nurr1, with an EC50 of 0.090 μM and a Kd of 0.17 μM. It activates Nurr1 homodimers (NurRE, EC50 = 0.094 μM) and Nurr1-RXR heterodimers (DR5, EC50 = 0.165 μM) . This compound induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in Parkinson's disease organoid models and can penetrate the human brain endothelial cell barrier.
Field of Research
Cancer Biology; Pharmacology & Drug Discovery, Metabolism Research
Molecular Formula
C21H19ClN4O2
Storage Conditions
-20°C
Notes
For research use only.

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