RP-1664

• Target :

  PLK

• Related Pathways :

  Cell Cycle/Checkpoint

• Purity :

  0.9904

• Bioactivity :

  RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. This compound demonstrates exceptional selectivity over related kinases, disrupts centriole biogenesis in cancer cells leading to PLK4 and p21 protein accumulation, shows enhanced sensitivity in TRIM37-high-expressing cells, and exhibits antitumor activity in breast cancer and neuroblastoma research.

• Smiles :

  O=S(=O)(C1=CC(F)=C(C(F)=C1)N(C=2N=C(NC3=NNC(=C3)C)C(=C(N2)C=4N=CN(C4)C)C5CC5)C)C

• Molecular Formula :

  C23H24F2N8O2S

• Molecular Weight :

  514.55

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2980682-00-4