HDAC1-IN-9

• Target:

  HDAC

• Related Pathways:

  Chromatin/Epigenetic|||DNA Damage/DNA Repair

• Bioactivity:

  HDAC1-IN-9 (13c) is an HDAC1 inhibitor. It inhibits the HDAC1 enzyme with an IC50 value of 1.07 µM. This compound exhibits the strongest antiproliferative activity against HT-29 (human colon adenocarcinoma cells), with an IC50 of 1.78 ?M. In HCT-116 (human colon cancer cells), HDAC1-IN-9 significantly induces apoptosis. Additionally, HDAC1-IN-9 possesses antiangiogenic properties, reducing the expression levels of VEGFR-2 and phosphorylated VEGFR-2 (pVEGFR-2) by approximately 80%.

• Molecular Formula:

  C17H17N3O3

• Molecular Weight:

  311.34

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C