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TZEP7

CAT: 0931-T205353-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205353-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2566714-41-6
Target
EGFR, Caspase, Apoptosis, Bcl-2 Family
Related Pathways
JAK/STAT signaling, Proteases/Proteasome, Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis
Bioactivity
TZEP7 functions as an EGFR kinase inhibitor in cancer cells. It exhibits cytotoxicity and induces apoptosis within these cells. TZEP7 downregulates the anti-apoptotic protein Bcl-2, upregulates the pro-apoptotic protein Bax, and increases caspase levels. This compound holds potential for research in anticancer drug development.
Smiles
C(\C#CC1=CC=CC=C1)=C/2\SC(=CC(=NC2)C3=CC(C)=C(F)C=C3)C4=CC=C(Cl)C=C4
Molecular Formula
C27H19ClFNS
Molecular Weight
443.963
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

(2Z)-7-(4-chlorophenyl)-5-(4-fluoro-3-methylphenyl)-2-(3-phenylprop-2-ynylidene)-3H-1,4-thiazepine
CAS Number2566714-41-6
PubChem CID176455425
IUPAC Name(2Z)-7-(4-chlorophenyl)-5-(4-fluoro-3-methylphenyl)-2-(3-phenylprop-2-ynylidene)-3H-1,4-thiazepine
Molecular FormulaC27H19ClFNS
Molecular Weight444.0
XLogP7.2
Topological Polar Surface Area37.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count31
Formal Charge0
Complexity774
SMILES
CC1=C(C=CC(=C1)C2=NC/C(=C/C#CC3=CC=CC=C3)/SC(=C2)C4=CC=C(C=C4)Cl)F
InChI
InChI=1S/C27H19ClFNS/c1-19-16-22(12-15-25(19)29)26-17-27(21-10-13-23(28)14-11-21)31-24(18-30-26)9-5-8-20-6-3-2-4-7-20/h2-4,6-7,9-17H,18H2,1H3/b24-9-
InChIKey
MMZFTVSVRUMVEY-OPVMPGTRSA-N
Chemical Structure
2D Structure
2D structure of (2Z)-7-(4-chlorophenyl)-5-(4-fluoro-3-methylphenyl)-2-(3-phenylprop-2-ynylidene)-3H-1,4-thiazepine
CAS: 2566714-41-6
CID: 176455425
Formula: C27H19ClFNS
MW: 444.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight444.0
XLogP37.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass443.0910766
Monoisotopic Mass443.0910766
Topological Polar Surface Area37.7 Ų
Heavy Atom Count31
Formal Charge0
Complexity774
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19249425-01TZEP7

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