TRPV1-IN-3

• Target:

  TRP/TRPV Channel

• Related Pathways:

  Membrane transporter/Ion channel

• Bioactivity:

  TRPV1-IN-3 (compound 14) is a TRPV1 inhibitor utilized in idiopathic pulmonary fibrosis research. It demonstrates antifibrotic activity in vitro (IC50 = 0.51 ?M) by inhibiting the TGF-?/Smads and MAPK pathways, thereby affecting the expression of fibrosis markers collagen I and ?-SMA. In vivo, TRPV1-IN-3 significantly reduces collagen deposition in lung tissue, improves alveolar structure, and increases survival rates in mice with Bleomycin-induced pulmonary fibrosis.

• Smiles:

  C(=C/C(CCCCC1=CC=CC=C1)=O)\C2=CC(O)=C(O)C=C2

• Molecular Formula:

  C19H20O3

• Molecular Weight:

  296.36

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  87657-67-8