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TRPV1-IN-3

CAT: 0804-HY-170839Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170839Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRPV1-IN-3 (compound 14) is a TRPV1 inhibitor that can be used for the research of idiopathic pulmonary fibrosis. TRPV1-IN-3 affects the expression of fibrosis markers collagen I and α-SMA by inhibiting the TGF-β/Smads and MAPK pathways, thereby exerting antifibrotic activity in vitro (IC50=0.51 μM). TRPV1-IN-3 significantly inhibits collagen deposition in lung tissue, improves the alveolar structure, and also increases the survival rate of mice with pulmonary fibrosis induced by Bleomycin.
CAS Number
87657-67-8
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(CCCCC1=CC=CC=C1)/C=C/C2=CC(O)=C(C=C2)O
Molecular Formula
C19H20O3
Molecular Weight
296.36
References & Citations
[1]Cao Y, et al. Discovery of novel capsaicin analogs as TRPV1 inhibitors for the treatment of idiopathic pulmonary fibrosis. Eur J Med Chem. 2025 Feb 15;284:117229.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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