WR-S-462

CAT: 0931-T205090-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T205090-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
STAT|||Bcl-2 Family
Related Pathways
JAK/STAT signaling|||Stem Cells|||Apoptosis
Bioactivity
WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 ?M, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC) .
Molecular Formula
C24H22N4O4S
Molecular Weight
462.52
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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