WR-S-462

• Target:

  STAT|||Bcl-2 Family

• Related Pathways:

  JAK/STAT signaling|||Stem Cells|||Apoptosis

• Bioactivity:

  WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 ?M, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC) .

• Molecular Formula:

  C24H22N4O4S

• Molecular Weight:

  462.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C