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Pyrimidinone 8

CAT: 0931-T205042-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205042-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
65004-42-4
Target
Ferroportin
Related Pathways
Membrane transporter/Ion channel
Bioactivity
Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1) . It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.
Smiles
O=C1N=C(NC(=C1)C)N2N=C(C=C2C)C
Molecular Formula
C10H12N4O
Molecular Weight
204.229
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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