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Meayamycin B

CAT: 0013-GTR19274926-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274926-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Meayamycin B ((+) -Meayamycin B) is a potent SF3B1 inhibitor that modulates pre-mRNA splicing to increase the expression of pro-apoptotic protein Mcl-1S and decrease Mcl-1L expression, without affecting the alternative splicing of Bcl-x. It synergizes with ABT-737 to induce apoptosis and demonstrates anticancer activity against non-small cell lung cancer.
CAS Number
1020210-12-1
Smiles
O[C@H]1[C@]2 (CO2) CC (C) (C) O[C@@H]1/C=C/C (=C/C[C@H]3[C@@H] (C) C[C@@H] (NC (/C=C\[C@@H] (OC (=O) N4CCOCC4) C) =O) [C@@H] (C) O3) /C
Molecular Formula
C31H48N2O8
Molecular Weight
576.73
Storage Conditions
-20°C
Notes
For research use only.

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