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3′-Me Meayamycin D

CAT: 0013-GTR19249812-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249812-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
3’-Me Meayamycin D is a potent SF3B1/PHF5A-targeting splice modulator that downregulates MCL-1. It inhibits proliferation in cancer cell lines (e.g., HCT116, A549) with GI50 values of 4.6-7.2 nM and exhibits good in vivo plasma stability (t1/2 ~16 h in mice), supporting its use in oncology and splicing mechanism research.
Smiles
C[C@H]1C[C@H] ([C@H] (O[C@H]1C/C=C (\C) /C=C/[C@@H]2[C@H] ([C@@]3 (CC (O2) (C) C) CO3) O) C) NC (=O) /C=C (/C) \[C@H] (C) OCOC
Molecular Formula
C29H47NO7
Molecular Weight
521.686
Storage Conditions
-20°C
Notes
For research use only.

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