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EGFR-IN-136

CAT: 0931-T204771-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204771-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling
Bioactivity
EGFR-IN-136 (compound 21v) is a potent inhibitor of EGFR, demonstrating IC50 values of 20.2 nM, 1.2 nM, 2.3 nM, and 12.5 nM for EGFRWT, EGFRLR/TM, EGFR19D/TM/CS, and EGFRLR/TM/CS, respectively. It exhibits antiproliferative and antitumor activities and holds potential for research in non-small cell lung cancer (NSCLC) .
Smiles
CC1=CN=C2NC3=C(C=C(C(=C3)C4=CN(CCCOC5=CC(=C(C=C5)NC1=N2)P(=O)(C)C)N=C4)N6CCOCC6)OC
Molecular Formula
C30H36N7O4P
Molecular Weight
589.625
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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