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VEGFR-2-IN-58

CAT: 0931-T204438-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204438-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, VEGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis
Bioactivity
VEGFR-2-IN-58 (Compound 7b) is a VEGFR-2 inhibitor with an IC50 of 42.5 nM. It shows selective cytotoxicity against cancer cells, induces cell cycle arrest at the G2/M phase, and triggers apoptosis by increasing BAX expression and decreasing Bcl2 expression. Additionally, VEGFR-2-IN-58 hampers cancer cell wound closure.
Smiles
C1=CC=C(C=C1)C2=C(OC(=C2C#N)/N=C/NC3=CC=C(C=C3)Cl)C4=CC=CC=C4
Molecular Formula
C24H16ClN3O
Molecular Weight
397.856
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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