Antibacterial agent 256

• Target:

  Others|||Antibacterial

• Related Pathways:

  Others|||Microbiology/Virology

• Bioactivity:

  Antibacterialagent 256 (Compound C09) is an inhibitor of Type I signal peptidase (SPase I) . It targets Gram-positive bacteria, effectively inhibiting S. aureus ATCC 29213, E. faecium QF31, E. faecalis SF23-1, and S. suis P1/7, with MIC values ranging from 1-16 ?g/mL. In cancer cells HEp-2 and Caco-2, Antibacterialagent 256 exhibits cytotoxicity with CC50 values of 14.65 ?g/mL and 21.93 ?g/mL, respectively. Additionally, it shows hemolytic activity on mouse red blood cells with an HC50 of 13.29 ?g/mL and can improve MRSA skin infections in mouse models.

• Smiles:

  C(O)(=O)C1=C2C(\C(=C\C=3SC(=CC3)C4=CC(C(F)(F)F)=C(Cl)C=C4)\CC(C)C2)=NC=5C1=CC=CC5

• Molecular Formula:

  C27H19ClF3NO2S

• Molecular Weight:

  513.96

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3052804-28-8