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KNa1.1-IN-2

CAT: 0931-T203619-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203619-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3037315-44-6
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
KNa1.1-IN-2 (Compound Z05) is a selective KNa1.1 channel inhibitor capable of penetrating the blood-brain barrier, and exhibits significant efficacy on hERG channels. It binds to KNa1.1 channels, effectively blocking channel activity caused by Gain-of-function (GOF) mutations, thus intervening in KCNT1-related seizures. Additionally, it inhibits the GOF mutant Y796H, making KNa1.1-IN-2 a promising candidate for research into KCNT1-associated epilepsy disorders.
Smiles
O(C=1C=CC=2C=CC=CC2C1CCC3CCNCC3)CC=4C=CC=CC4
Molecular Formula
C24H27NO
Molecular Weight
345.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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