BBO-10203

CAT: 0931-MF-0097810-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0097810-01Size:1 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2971769-60-3
Target
Akt|||PI3K
Related Pathways
PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling
Purity
0.9987
Bioactivity
BBO-10203 is an orally active small molecule, also designated as Compound 758, that functions as a selective PI3K?-Ras interaction disruptor by binding to the Ras-binding domain of PI3K?. BBO-10203 effectively prevents Ras-PI3K? complex formation, inhibits downstream Akt activation without altering basal PI3K? kinase activity, thereby minimizing risks of hyperglycemia and hyperinsulinemia, and displays selective antitumor activity against KRAS-mutant malignancies, making it an important investigational candidate for targeted cancer therapeutics.
Smiles
O=C(C=C)N1CCN2N=C(C=C2C1C)C=3N=C(C=4C=CC5=C(C=NN5C)C4)C=6C=CSC6C3C7=C(F)C=C(F)C=C7OCCOC
Molecular Formula
C34H30F2N6O3S
Molecular Weight
640.7
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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