SET-171

• Target :

  JNK|||PKM

• Related Pathways :

  MAPK|||Metabolism

• Bioactivity :

  SET-171 is a JNK (c-Jun N-terminal kinase) inhibitor that exhibits significant anticancer activity by suppressing the expression of hepatic pyruvate kinase (PKL) and offers potential in regulating lipid metabolism. In antitumor studies, SET-171 shows notable cytotoxicity against human liver cancer cell lines HepG2 and Huh7, with IC50 values of 8.82 ?M and 2.97 ?M, respectively. Additionally, in research related to non-alcoholic fatty liver disease (NAFLD), SET-171 significantly reduces triglyceride (TAG) levels and inhibits the expression of proteins associated with steatosis. This compound holds promise for hepatocellular carcinoma (HCC) and NAFLD research.

• Smiles :

  N#CC1=C(SC2=C1CCN(CC(=O)NC=3C=CC=C(Br)C3)C2)NC(=O)C4=CC=CC=5C=CC=CC54

• Molecular Formula :

  C27H21BrN4O2S

• Molecular Weight :

  545.45

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3052985-32-4