SET-171

CAT: 0931-T203280-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T203280-01Size:10 mg
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CAS Number
3052985-32-4
Target
JNK|||PKM
Related Pathways
MAPK|||Metabolism
Bioactivity
SET-171 is a JNK (c-Jun N-terminal kinase) inhibitor that exhibits significant anticancer activity by suppressing the expression of hepatic pyruvate kinase (PKL) and offers potential in regulating lipid metabolism. In antitumor studies, SET-171 shows notable cytotoxicity against human liver cancer cell lines HepG2 and Huh7, with IC50 values of 8.82 ?M and 2.97 ?M, respectively. Additionally, in research related to non-alcoholic fatty liver disease (NAFLD), SET-171 significantly reduces triglyceride (TAG) levels and inhibits the expression of proteins associated with steatosis. This compound holds promise for hepatocellular carcinoma (HCC) and NAFLD research.
Smiles
N#CC1=C(SC2=C1CCN(CC(=O)NC=3C=CC=C(Br)C3)C2)NC(=O)C4=CC=CC=5C=CC=CC54
Molecular Formula
C27H21BrN4O2S
Molecular Weight
545.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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