IRF1-IN-2

• Target:

  Pyroptosis|||Caspase|||PARP|||Interleukin|||Glutathione Peroxidase|||IFNAR

• Related Pathways:

  Chromatin/Epigenetic|||Metabolism|||Apoptosis|||DNA Damage/DNA Repair|||Proteases/Proteasome|||Immunology/Inflammation

• Purity:

  0.9985

• Bioactivity:

  IRF1-IN-2 is a small molecule inhibitor of interferon regulatory factor 1 (IRF1) that functions by reducing the binding affinity of IRF1 for the caspase-1 (CASP1) gene promoter. this inhibition subsequently suppresses critical cell death signaling pathways, such as pyroptosis, and provides robust protection against ionizing radiation-induced skin inflammatory damage in preclinical models.

• Smiles:

  O=C (NC1=CC=C (C=C1) S (=O) (=O) N2CCCC2) C=3C=CC=CC3OC

• Molecular Formula:

  C18H20N2O4S

• Molecular Weight:

  360.43

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  708245-32-3