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IRF1-IN-2

CAT: 0931-T203076-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T203076-01Size:1 mL - 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
708245-32-3
Target
Pyroptosis, Caspase, PARP, Interleukin, Glutathione Peroxidase, IFNAR
Related Pathways
Chromatin/Epigenetic, Metabolism, Apoptosis, DNA Damage/DNA Repair, Proteases/Proteasome, Immunology/Inflammation
Purity
0.9985
Bioactivity
IRF1-IN-2 is a small molecule inhibitor of interferon regulatory factor 1 (IRF1) that functions by reducing the binding affinity of IRF1 for the caspase-1 (CASP1) gene promoter. this inhibition subsequently suppresses critical cell death signaling pathways, such as pyroptosis, and provides robust protection against ionizing radiation-induced skin inflammatory damage in preclinical models.
Smiles
O=C(NC1=CC=C(C=C1)S(=O)(=O)N2CCCC2)C=3C=CC=CC3OC
Molecular Formula
C18H20N2O4S
Molecular Weight
360.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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