APOL1-IN-2

• Target:

  Apolipoprotein

• Related Pathways:

  Metabolism

• Bioactivity:

  APOL1-IN-2 (Compound 467) acts as an inhibitor of apolipoprotein L1 (APOL1) . It effectively reduces HEK293 cell death induced by APOL1 G2/G1, with EC50 values of 4.74 nM and 14.3 nM, respectively. Additionally, APOL1-IN-2 decreases the mortality of trypanosomes triggered by APOL1 G2/G1/G0, with EC50 values of 2.24, 6.03, and 3.72 nM, respectively.

• Smiles:

  O=C1C2(C=3C(N1)=CC=C(Cl)C3)CCN(CCOC=4C=C5C(=C(C(F)(F)F)C4)N(C(=O)N5CO)[C@H]6C[C@@](C)(O)C6)CC2

• Molecular Formula:

  C28H30ClF3N4O5

• Molecular Weight:

  595.01

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2956781-84-1