APOL1-IN-2

• Description:

  APOL1-IN-2 (Compound 467) is the inhibitor for Apolipoprotein 1 (APOL1) . APOL1-IN-2 reduces the APOL1 G2/G1 induced cell death in HEK293 with EC50 of 4.74 nM and 14.3 nM. APOL1-IN-2 reduces the APOL1 G2/G1/G0 induced death of trypanosomes with EC50 of 2.24, 6.03 and 3.72 nM, respectively[1].

• UNSPSC:

  12352005

• Target:

  Apolipoprotein

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Infection

• Smiles:

  O=C(N1[C@@H]2C[C@](C)(O)C2)N(CO)C3=C1C(C(F)(F)F)=CC(OCCN(CC4)CCC4(C(N5)=O)C6=C5C=CC(Cl)=C6)=C3

• Molecular Formula:

  C28H30ClF3N4O5

• Molecular Weight:

  595.01

• References & Citations:

  [1]Lee PST, et al., APOL1 inhibitors and methods of use. US11976067B2

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2956781-84-1]