NS-062

• Target:

  Antibacterial|||EGFR

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Microbiology/Virology

• Bioactivity:

  NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 ?M. It also exhibits antitumor activity in a murine H1975 xenograft model.

• Smiles:

  N (C=1C2=C (C=C (OCCCN3CCOCC3) C (NC (=O) [C@@H]4N (C (C (Cl) F) =O) CCC4) =C2) N=CN1) C5=CC (Cl) =C (F) C=C5

• Molecular Formula:

  C28H30Cl2F2N6O4

• Molecular Weight:

  623.48

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2226257-92-5