NS-2028

• Target:

  Guanylate cyclase

• Related Pathways:

  GPCR/G Protein

• Purity:

  0.9944

• Bioactivity:

  NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity) commonly used in nitric oxide signaling pathway research. It inhibits sGC activity in mouse cerebellum homogenates and neuronal NO synthase (IC50: 17 nM and 20 nM), inhibits 3-morpholino-sydnonimine (SIN-1) -elicited cyclic GMP formation in human cultured umbilical vein endothelial cells (IC50: 30 nM), and completely inhibits NO-dependent relaxant responses in non-vascular smooth muscle (1 ?M) . NS-2028 also decreases vascular endothelial growth factor-induced angiogenesis and permeability.

• Smiles:

  Brc1ccc2OCc3noc (=O) n3-c2c1

• Molecular Formula:

  C9H5BrN2O3

• Molecular Weight:

  269.05

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  204326-43-2