TGase2-IN-1

CAT: 0931-T201596-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T201596-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2244702-64-3

Target

Glutaminase, Ligands for Target Protein for PROTAC

Related Pathways

Proteases/Proteasome, PROTAC

Bioactivity

TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 μM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 μM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.

Smiles

O=C1C=C(N)C(=O)C2=NC(=CC=C12)C=3C=CC(OC4CCN(CC4)C(C)C)=CC3

Molecular Formula

C23H25N3O3

Molecular Weight

391.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
GTR19240519-01	TGase2-IN-1
sc-73612	TGase2 (4G3)
395303	TGase2 discontinued
C0350-01	TGase2 Antibody
sc-270266	TGase2 siRNA (r)
RA30432-01	TGase2 Polyclonal Antibody
sc-73612 FITC	TGase2 (4G3) FITC
sc-37514	TGase2 siRNA (h)
sc-37514-PR	TGase2 (h) -PR
STJ95990	Anti-TGase2 antibody

TGase2-IN-1

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