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TRPM7-IN-1

CAT: 0931-T201413-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201413-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1909225-07-5
Target
PI3K, Akt, Apoptosis, Antibacterial
Related Pathways
Microbiology/Virology, PI3K/Akt/mTOR signaling, Apoptosis, Cytoskeletal Signaling
Bioactivity
TRPM7-IN-1 (compound SUD) is a benzamide-urea derivative and an effective inhibitor of TRPM7. This compound induces cell cycle arrest and apoptosis in MCF-7 and BGC-823 cells, reducing their migration capabilities. It decreases vimentin expression while increasing E-cadherin expression. TRPM7-IN-1 reduces TRPM7-like currents and inhibits TRPM7 expression by activating the PI3K/Akt signaling pathway. This compound shows potential as a therapeutic agent for reducing breast and gastric cancer metastasis by targeting TRPM7 expression and activity.
Smiles
O=C(NC(=O)C=1C=CC=CC1N(C)C)NC2=CC=C(OC=3N=C(C=C(N3)C)C)C(=C2)C
Molecular Formula
C23H25N5O3
Molecular Weight
419.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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