Products for Research Use Only
RegisterLogin

AZ 14145845

CAT: 0931-T201375-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T201375-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2830555-70-7
Bioactivity
AZ 14145845, a potent and highly selective dual Mer/Axl kinase inhibitor (pIC50 = 7 nM and 7.8 nM in pAxl and pMer, respectively), demonstrates significant efficacy in reducing tumor growth in a dose-dependent manner within the Mer and Axl kinase Ba/F3 tumor xenograft model in vivo. When combined with anti-PD1 antibodies and ionizing radiation, this compound enhances survival rates in mice bearing MC38-derived tumors. Additionally, AZ 14145845 is orally bioavailable.
Smiles
N=1N=C(OC1C=2N=CC(=CC2C)C=3C(=NN(C3C)C)C)N(C)CC=4C=CC5=NC=C(C=6C=CC(=CC6)CN(C)C)N5C4
Molecular Formula
C32H35N9O
Molecular Weight
561.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T70741-01AZ-TAK1
T68668-01AZ-1
T6318-01AZ 628
T13563-01AZ-1355
T35942-01AZ 5704
T70502-01AZ-27
T68696-01AZ-2
T211816-01AZ'320
T209551-01AZ'9567
T74060-01AZ'6421

Alternative Products

CatalogName
8023/10AZ 14145845

Popular Products