D34-919

• CAS Number :

  1011641-78-3

• Target :

  Dehydrogenase|||PKM

• Related Pathways :

  Metabolism

• Bioactivity :

  D34-919 is a potent inhibitor of the ALDH1A3-PKM2 interaction, effectively inhibiting the ALDH1A3-mediated tetramerization enhancement of PKM2. Treatment mediated by D34-919 both in vitro and in vivo enhances and restores apoptosis and sensitivity in glioblastoma (GBM) cells induced by radiochemotherapy.

• Smiles :

  N#CC=1C(=NC(=NC1N2CCC(C(=O)N)CC2)SC)C=3C=CC(=CC3)C(C)(C)C

• Molecular Formula :

  C22H27N5OS

• Molecular Weight :

  409.55

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C