GS-9191

• Target:

  Apoptosis|||DNA/RNA Synthesis|||Virus Protease

• Related Pathways:

  Cell Cycle/Checkpoint|||Microbiology/Virology|||DNA Damage/DNA Repair|||Apoptosis

• Purity:

  0.9928

• Bioactivity:

  GS-9191 is a potent inhibitor of DNA polymerase alpha and ß , a prodrug of the novel nucleoside analogue 9- (2-phosphonomethoxyethyl) guanine (PMEG), which penetrates the skin and is metabolized in the epithelium to an active nucleoside triphosphate analogue.GS-9191 has antiproliferative activity and reduces the size of papillomas in a dose-related manner.GS-9191 may be useful in the treatment of HPV-induced lesions.

• Smiles:

  C(COCP(N[C@@H](CC1=CC=CC=C1)C(OCC(C)C)=O)(N[C@@H](CC2=CC=CC=C2)C(OCC(C)C)=O)=O)N3C=4C(=C(NC5CC5)N=C(N)N4)N=C3

• Molecular Formula:

  C37H51N8O6P

• Molecular Weight:

  734.82

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  859209-84-0