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GS-9191

CAT: 0931-T25466-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T25466-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
859209-84-0
Target
Apoptosis, DNA/RNA Synthesis, Virus Protease
Related Pathways
Cell Cycle/Checkpoint, Microbiology/Virology, DNA Damage/DNA Repair, Apoptosis
Purity
0.9928
Bioactivity
GS-9191 is a potent inhibitor of DNA polymerase alpha and ß , a prodrug of the novel nucleoside analogue 9- (2-phosphonomethoxyethyl) guanine (PMEG), which penetrates the skin and is metabolized in the epithelium to an active nucleoside triphosphate analogue.GS-9191 has antiproliferative activity and reduces the size of papillomas in a dose-related manner.GS-9191 may be useful in the treatment of HPV-induced lesions.
Smiles
C(COCP(N[C@@H](CC1=CC=CC=C1)C(OCC(C)C)=O)(N[C@@H](CC2=CC=CC=C2)C(OCC(C)C)=O)=O)N3C=4C(=C(NC5CC5)N=C(N)N4)N=C3
Molecular Formula
C37H51N8O6P
Molecular Weight
734.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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