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WS-11

CAT: 0013-GTR19239661-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19239661-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WS-11 is a potent, reversible non-covalent inhibitor of both wild-type (IC50=3.9 nM) and C481S mutant (IC50=2.2 nM) BTK, stabilized by key hydrogen bonds and π-interactions with residues PHE540 and LYS430. It is a valuable chemical probe for studying B-cell signaling pathways in both cellular and animal models of autoimmune diseases and B-cell malignancies.
CAS Number
2759280-09-4
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O=C1N=C (C=C1) N2CCCC (N3N=C (C=4C=CC (=CC4F) C (=O) NC5=NC=CC=C5) C=6C (=NC=NC63) N) C2
Molecular Formula
C26H22FN9O2
Molecular Weight
511.51
Storage Conditions
-20°C
Notes
For research use only.

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