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SJ46421

CAT: 0931-T200999-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200999-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Epigenetic Reader Domain, PROTACs
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
SJ46421, a PROTAC protein degrader derived from (+) -JQ-1, targets KLHDC2. It efficiently forms a stable ternary complex with KLHDC2, exhibiting an IC50 of 7.8 nM. Furthermore, SJ46421 promotes the polyubiquitination of the BD2 domain of BRD2, BRD3, or BRD4.
Smiles
N#CC=1C=NN2C=C(C=C(C=3C=NC(=CC3)N4CC5N(CC6=CN=C(OC)C=C6)C(C4)C5)C12)N7CC(O)(C)C7
Molecular Formula
C42H41ClN8O5S2
Molecular Weight
837.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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