CV-4-26

• Target:

  Apoptosis|||YAP

• Related Pathways:

  Stem Cells|||Apoptosis

• Bioactivity:

  CV-4-26 (Compound 22) acts as a covalent inhibitor of TEAD. By inhibiting YAP/TEAD-driven transcription, it diminishes the expression of CTGF and CYR61. Furthermore, CV-4-26 impedes colony formation in Huh7 and HepG2 cells, inducing cell cycle arrest and apoptosis (apoptosis) . This compound demonstrates anti-tumoral activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB) .

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C