NOD1-IN-1

• Target:

  NOD-like Receptor (NLR)

• Related Pathways:

  Immunology/Inflammation

• Bioactivity:

  NOD1/2-IN-1 (Compound 2) is a potent inhibitor of RIPK2 with an IC50 value of 0.65 nM as determined by the ADP-Glo assay. It selectively inhibits the NOD1 pathway, with an IC50 of 33 nM, effectively blocking the production of pro-inflammatory cytokines and thereby reducing inflammatory responses. This compound has potential applications in the research of colitis.

• Smiles:

  ClC1=CC=C(C=C1O)NC=2N=CN=C3C=C(OC)C(OC)=CC32

• Molecular Formula:

  C16H14ClN3O3

• Molecular Weight:

  331.75

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  687627-78-7