Products for Research Use Only
RegisterLogin

Bayer-18

CAT: 0931-T200632-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T200632-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1251752-12-1
Target
Apoptosis, JAK
Related Pathways
Stem Cells, Chromatin/Epigenetic, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Apoptosis
Bioactivity
Bayer-18 is an inhibitor of TYK2. It inhibits the viability of anaplastic large cell lymphoma cells, including K299, SR786, Mac1, and Mac2a, with an IC50 ranging from 2-3 μM. Additionally, Bayer-18 induces apoptosis in K299 and SR786 cells.
Smiles
O=C(NC1=CC=CC(=C1)NC2=NC=C(F)C(=N2)NC(C)(C)CO)NC(C)(C)C
Molecular Formula
C19H27FN6O2
Molecular Weight
390.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

1-(Tert-butyl)-3-(3-((5-fluoro-4-((1-hydroxy-2-methylpropan-2-yl)amino)pyrimidin-2-yl)amino)phenyl)urea
CAS Number1251752-12-1
PubChem CID73265273
IUPAC Name1-tert-butyl-3-[3-[[5-fluoro-4-[(1-hydroxy-2-methylpropan-2-yl)amino]pyrimidin-2-yl]amino]phenyl]urea
Molecular FormulaC19H27FN6O2
Molecular Weight390.5
XLogP2.4
Topological Polar Surface Area111
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count28
Formal Charge0
Complexity513
SMILES
CC(C)(C)NC(=O)NC1=CC=CC(=C1)NC2=NC=C(C(=N2)NC(C)(C)CO)F
InChI
InChI=1S/C19H27FN6O2/c1-18(2,3)26-17(28)23-13-8-6-7-12(9-13)22-16-21-10-14(20)15(24-16)25-19(4,5)11-27/h6-10,27H,11H2,1-5H3,(H2,23,26,28)(H2,21,22,24,25)
InChIKey
DYNMZYFOSRSMAC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(Tert-butyl)-3-(3-((5-fluoro-4-((1-hydroxy-2-methylpropan-2-yl)amino)pyrimidin-2-yl)amino)phenyl)urea
CAS: 1251752-12-1
CID: 73265273
Formula: C19H27FN6O2
MW: 390.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight390.5
XLogP32.4
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass390.21795229
Monoisotopic Mass390.21795229
Topological Polar Surface Area111 Ų
Heavy Atom Count28
Formal Charge0
Complexity513
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T30306-01Bayer 9017
TMID-0178-01Stearic acid-18,18,18-d3
T31040CP-18 F-18
TCL-00013-0118:0-18:2 PE
T205670-0118:0-18:2 PG sodium
T205426-0118:0-18:1 PA sodium
T74759-0118:0,18:1 PS sodium
TYD-02396-0118-CoA-18-oxo-dinor-LTB4
T211060-01CDK-IN-18
T210265-01DHFR-IN-18

Alternative Products

CatalogName
GW9599-10mgBayer-18
442166Bayer 18
HY-117097Bayer 16574
HY-119853Bayer A 139
HY-118322Bayer 30468
MBS5779940Bayer 9017
1022-BAOCS CRM Rice Bayer Event LLRice62 powder, 10g
0808-A2Maize Bayer CropScience MON 87419 Powder 0818-A2, 10g
0521-AAOCS 0521-A event MON95379 Bayer CropScience Maize seed-powder (10g)
1221-AMaize Bayer CropScience Event MON95275 powder (10g) Certified Reference Material

Popular Products