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XJTU-L453

CAT: 0931-T200390-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200390-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3008290-92-1
Target
PI3K, Apoptosis
Related Pathways
Apoptosis, PI3K/Akt/mTOR signaling
Bioactivity
XJTU-L453, a PI3Kα inhibitor, exhibits an IC50 of 0.4 nM. It inhibits the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM respectively. Additionally, XJTU-L453 disrupts the PI3K pathway, leading to cell cycle arrest and cell apoptosis (apoptosis) . It also demonstrates antitumor activity in MCF7 xenograft mice.
Smiles
O([C@H](C(N)=O)C)C=1C=C2C(C=3C(CO2)=CC=C(C3)C=4C=C(NCC)N=CN4)=CC1
Molecular Formula
C22H22N4O3
Molecular Weight
390.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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