AJI-214

• Target:

  JAK|||Aurora Kinase|||STAT

• Related Pathways:

  Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells|||Angiogenesis|||Tyrosine Kinase/Adaptors

• Bioactivity:

  AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD) .

• Smiles:

  O=C (N) C1=CC=C (C=C1) NC2=NC=C (F) C (=N2) NC=3C=CC=CC3Cl

• Molecular Formula:

  C17H13ClFN5O

• Molecular Weight:

  357.77

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1395886-20-0