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AJI-100

CAT: 0931-T200052-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200052-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
844435-10-5
Target
Aurora Kinase, JAK, STAT
Related Pathways
JAK/STAT signaling, Cell Cycle/Checkpoint, Angiogenesis, Stem Cells, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic
Bioactivity
AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD) .
Smiles
O=C(N)C1=CC=C(C=C1)NC2=NC=C(F)C(=N2)NC=3C=CC=CC3
Molecular Formula
C17H14FN5O
Molecular Weight
323.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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